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Pharmacokinetics When taken orally, ciprofloxacin is rapidly absorbed from the digestive tract. The bioavailability of the drug is 50-85%. Cmax of the drug in the blood serum of healthy volunteers when taken orally (before meals) 250 mg, 500 mg, 750 mg and 1000 mg of the drug is reached after 1-1.5 hours and is 1.2 μg / ml, 2.4 μg / ml, 4.3 μg / ml and 5.4 μg / ml, respectively. Orally taken ciprofloxacin is distributed in tissues and body fluids. High concentrations of the drug are observed in bile, lungs, kidneys, liver, gall bladder, uterus, seminal fluid, prostate tissue, tonsils, endometrium, fallopian tubes and ovaries. The concentration of the drug in these tissues is higher than in serum. Ciprofloxacin also penetrates well into bones, ocular fluid, bronchial secretions, saliva, skin, muscles, pleura, peritoneum, and lymph.